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冯莉莉

Feng Li Li

部门：材料科学与化学工程学院

学科：材料科学与工程

职务：

职称：副教授

指导资格：博士生导师
硕士生导师

电话： +8618845109691

传真：

邮箱： fenglili@hrbeu.edu.cn

邮编： 150001

地址：哈尔滨工程大学基础实验楼447室

个人简介

冯莉莉，副教授，博导，国家级人才项目入选者（2023年），黑龙江省B类高层次人才，德国洪堡学者。目前主要从事方向为生物大分子药物递送载体的设计与疾病治疗，迄今为止在国际SCI刊物上已发表论文45余篇，其中以第一/通讯作者在Science Advances、Advanced Materials、Advanced Functional Materials、ACS Nano、Small、Biomaterials、Chemistry of Materials等国际期刊发表SCI收录论文40余篇，Science子刊一篇，ESI高被引论文4篇，SCI 他引频次3000余次，H因子34。主持承担国家自然科学基金青年基金项目，德国“洪堡学者”研究项目、中国博士后科学基金面上项目及中央高校科研业务经费项目等13项，国家自然科学基金面上项目主要参与人。申请国家发明专利8项，已获授权专利6项和受理专利4项。获德国洪堡学者研究奖（有德国亚历山大·冯·洪堡基金会资助）、黑龙江省高校科学技术特等奖1项（排名第3）、中国化工学会“化工与京博博士论文奖提名奖”、Vebleo协会会士等。受邀担任Military Medical Research、Fundamental Research、BEM Mat等期刊青年编委，Materials、Frontiers in Cell and Developmental Biology和Frontiers in Physiology期刊客座编辑；Advanced Mateirlas、Advanced Functional Materials、ACS Nano、Biomaterials、Theranostics、ACS Applied Materials & Interfaces等顶级学术期刊特邀审稿人及ICNST、Nano Mat等国际会议组委会委员。

教育经历

2015.09–2019.06, 工学博士，哈尔滨工程大学, 材料科学与化学工程学院，材料科学与工程专业
2014.09–2015.07, 工学硕士，哈尔滨工程大学, 材料科学与化学工程学院，化学工程与技术专业

工作经历

2021.11–至今，哈尔滨工程大学，材料科学与化学工程学院，副教授
2020.09–2021.09，University of Hamburg（德国）德国“洪堡学者”博士后研究员
2019.08–2020.09，Nanyang Technological University（新加坡）博士后研究员

研究方向

主要研究目标是开发具有多功能的药物递送平台技术，来提高药物的治疗效果。通过包括药学，化学，材料学，生物学及医学等交叉学科研究手段，制备具有生物兼容性好的药物载体，实现药物高效递送及有效治疗。

1、纳米佐剂与递送系统研究；

2、纳米材料的可控合成及其生物效应研究；

3、多模式生物成像技术与肿瘤治疗一体化。

承担项目

国家自然科学基金青年基金项目
德国“洪堡学者”研究项目（由德国亚历山大·冯·洪堡基金会资助）
中国博士后科学基金面上资助项目
黑龙江省博士后面上资助项目
黑龙江省回国人员择优资助项目
纤维材料改性国家重点实验室开放课题
启航培育计划项目
2020年、2021年、2022年自由探索计划项目
中央高校基本科研业务经费
首届哈尔滨工程大学博士科研创新基金项目

学术交流

学术交流与合作：
与德国汉堡大学Wolfgang J. Parak教授、新加坡南洋理工大学赵彦利教授保持长期的学术交流与合作

近期参加国内外学术会议情况：

The Webinar on Nanomedicine, Nanomaterials and Nanotechnology, 2022.9.28-30, 国际线上研讨会, 特邀报告；
中国稀土学会2022学术年会，2022.8.17-20，内蒙古包头市，邀请报告；

第四届国际二维过渡金属碳化物学术会议，2022.8.5-8，江苏南京；

Phosphor Safari 2022，the 12th Internation Symposium on Phosphor Materials, 2022.7.30-2022.08.03，兰州，邀请报告；

欧洲分子成像会议，2021.8.27-28，德国哥廷根，邀请报告；

德国洪堡基金会Network Meeting学术会议，2020.11.18-19，德国，口头报告；

ACS全球科技研讨会，2019.11.17-19，新加坡；

第七届掺杂纳米材料发光性能国际会议，2018.6.21-24，大连，口头报告；

第九届稀土发光材料国际会议，2017.12.1-3，广州；

首届黑龙江省材料博士生论坛，2016.12.23，哈尔滨，口头报告；

招生信息

可招收材料科学与工程、化学工程与技术、材料与化工学科博士研究生、硕士研究生。

本科生授课课程

化学工程与工艺专业，专业核心课程，化工热力学，授课年级：第三学年下学期；

研究生授课课程

材料与化工专业学位硕士研究生的必选课程，材料与化工安全工程。

实践性教学

材料科学与工程专业，专业核心课程，毕业实习，授课年级：第四学年下学期。

教学研究课题

《新工科背景下“化工热力学”专业课程教学改革研究》2022.05-2024.04 校级教学改革项目，项目编号：BKJG2022A03

社会兼职

Frontiers in Pharmacology期刊客座编辑；
Frontiers in Cell and Developmental Biology期刊客座编辑；
Materials期刊客座编辑；
Military Medical Research期刊青年编委；
European Society for Molecular Imaging 会议评审专家；
ACS Nano、Biomaterials、Theranostics和ACS Appl. Mater. & Interfaces等十余个国际期刊审稿人；
《当代化工研究》杂志编委；

专利成果

1. 冯莉莉等，一种近红外光响应的上转换介孔二氧化锡诊疗纳米胶囊的制备方法，专利号：ZL202111284507.0
2. 冯莉莉等，一种应用于肿瘤诊疗氧空位中空介孔二氧化锡的制备方法，申请号：202111283045.0
3. 冯莉莉等，一种用于检测过氧化氢和葡萄糖浓度的复合型量子点的制备方法，申请号：202111512296.1
4. 冯莉莉等，一种近红外光响应的锰离子掺杂二硒化钒纳米片的制备方法，专利号：ZL202210223296.8
5. 冯莉莉等，一种近红外光增强催化性能的铂锡双金属纳米粒子的制备方法，申请号：202210664711.3
6. 冯莉莉等，一种钒空位浓度差异的二维压电钒酸铋纳米片的制备方法，专利号：
7. 杨飘萍；田博士；冯莉莉；贺飞；盖世丽；一种具有类过氧化物酶活性碳点/多孔二氧化硅纳米酶的制备方法，2022-02-20，专利号：ZL202110831930.1
8. 杨飘萍；贺飞；冯莉莉；张强；杨桂欣；盖世丽；一种应用于光动力治疗的纳米复合材料及制备方法，2017-11-28，专利号：ZL201510689583.8

出版著作

发表论文

28. Lili Feng, Ruoxi Zhao, Lu Yang, Bin Liu, Shuming Dong, Cheng Qian, Jiawei Liu, and Yanli Zhao*. A Tumor-Specific NIR-Mediated Activatable Theranostic Nanoreactors for Self-Enhanced Multimodality Imaging and Cancer Phototherapy. ACS Nano, 2023, Accepted.
27. Shikai Liu, Linyang Fang, He Ding*, Yangyang Zhang, Wenting Li, Bin Liu, Shuming Dong, Boshi Tian, Lili Feng* and Piaoping Yang*. Alternative Strategy to Optimize Cerium Oxide for Enhanced X-Ray-Induced Photodynamic Therapy. ACS Nano. 2022, 16(12), 20805-20819.
26. Bin Liu, Lili Feng*, Yulong Bian, Yanlin Zhu, Bengang Xing, Piaoping Yang*, and Jun Lin*. Calcification of Indocyanine Green Laden Dendritic Mesoporous Manganese Silicon Nanocomposite for Multiple Oxygen Compensation Enhanced Phototherapy. Advanced Optical Materials. 2022, 202202022.
25. Lu Yang, Haixia Zhu, Ruoxi Zhao, Zhijia Zhang, Bin Liu, Yanlin Zhu, Haijiang Gong, He Ding, Shili Gai, and Lili Feng*. Tumor Microenvironment Activated Glutathione Self-Depletion Theranostic Nanocapsules for Imaging-Directed Synergistic Cancer Therapy. Chemical Engineering Journal, 2022, 450, 138137.
24. Ruoxi Zhao, Yanlin Zhu, Jialing Zhou, Bin Liu, Yaqian Du, Shili Gai, Ruifang Shen, Lili Feng*, and Piaoping Yang*. Dual Glutathione Depletion Enhanced Enzyme Catalytic Activity for Hyperthermia Assisted Tumor Therapy on Semi-Metallic VSe2/Mn-CS. ACS Nano, 2022, 16(7), 10904–10917.
23. Boshi Tian, Yaqian Du, Shuming Dong, Lili Feng*, Bin Liu, Shikai, Liu, He Ding*, Shili Gai, Fei He, and Piaoping Yang*. NIR-Triggered Theranostic Nanoplatform with Controlled Release of HSP90 Inhibitor for Synergistic Mild-Photothermal and Enhanced Nanocatalytic Therapy Against Hypoxic Tumor. Small, 2022，2200786.
22. Jialing Zhou, Ruoxi Zhao, Yaqian Du, Shikai Liu, Wenting Li, Shili Gai, Fei He, Lili Feng,* Piaoping Yang*. A Si-CdTe Composite Quantum Dots Probe with Dual-Wavelength Emission for Sensitively Monitoring Intracellular H^₂O^₂. Advanced Functional Materials, 2022, 2112083.
21. Yanlin Zhu, Zhao Wang, Ruoxi Zhao, Yiheng Zhou, Lili Feng,* Shili Gai,* and Piaoping Yang*. Pt Decorated Ti^₃C^₂T^_x MXene with NIR-II Light Amplified Nanozyme Catalytic Activity for Efficient Phototheranostics. ACS Nano, 2022, DOI: 10.1021/acsnano.1c10732（ESI高被引论文）.
20. Lu Yang, Ruipeng Shi, Ruoxi Zhao, Yanlin Zhu, Bin Liu, Shili Gai, and Lili Feng*. Near-Infrared Upconversion Mesoporous Tin Dioxide Theranostic Nanocapsules for Synergetic Cancer Chemophototherapy. ACS Applied Materials&Interfaces. 2022, 14(2), 2650-2662.
19. Yaofeng Zhou, Siyu Fan, Lili Feng*, Xiaolin Huang*, Xiaoyuan Chen*. Manipulating Intratumoral Fenton Chemistry for Enhanced Chemodynamic and Chemodynamic-Synergized Multimodal Therapy. Advanced Materials. 2021, 33, 2104223.
18. Dingcheng Zhu, Lili Feng, Neus Feliu, Andreas Guse, Wolfgang J. Parak*. Stimulation of local cytosolic calcium release by photothermal heating for studying intra- and inter-cellular calcium waves. Advanced Materials. 2021, 33 (24), 2170184.
17. Lili Feng, Bin Liu, Rui Xie, Dongdong Wang, Cheng Qian, Weiqiang Zhou, Jiawei Liu, Deblin Jana, Piaoping Yang,* and Yanli Zhao*. An Ultrasmall SnFe^₂O^₄ Nanozyme with Endogenous Oxygen Generation and Glutathione Depletion for Synergistic Cancer Therapy. Advanced Functional Materials, 2020, 2006216.
16. Lili Feng, Shili Gai, Fei He, Piaoping Yang,* and Yanli Zhao*. Multifunctional Bismuth Ferrite Nanocatalysts with Optical and Magnetic Functions for Ultrasound-Enhanced Tumor Theranostics. ACS Nano, 2020, 11(13), 13144-13160.
15. Lili Feng,* Ruoxi Zhao, Bin Liu, Fei He, Shili Gai, Yujin Chen, and Piaoping Yang*. Near-Infrared Upconversion Mesoporous Tin Oxide Bio-Photocatalyst for H^₂O^₂-Activatable O^₂-Generating Magnetic Targeting Synergetic Treatment. ACS Applied Materials & Interfaces, 2020, 12(37): 12993-13008.
14. Lili Feng, Cheng Qian, Yanli Zhao*. Recent Advances in Covalent Organic Framework-Based Nanosystems for Bioimaging and Therapeutic Applications. ACS Materials Letters, 2020, 2(9), 1074-1092.
13. Lili Feng, Yanli Zhao*. Research Progress in Endogenous H^₂S-Activatable Nanoplatforms for Cancer Theranostics. View, 2020, 1 (2), e15.
12. Jun Yang, Rui Xie, Lili Feng,* Bin Liu, Ruichan Lv, Chunxia Li, Shili Gai, Fei He, Piaoping Yang,* and Jun Lin*. Hyperthermia and Controllable Free Radicals Co-Enhanced Synergistic Therapy in Hypoxia Enabled by NIR-II Light Irradiation. ACS Nano, 2019, 14(6), 7245-7258.
11. Lili Feng, Rui Xie, Chuanqing Wang, Shili Gai,* Fei He, Dan Yang, Piaoping Yang,* and Jun Lin*. Magnetic Targeting, Tumor Microenvironment Responsive Intelligent Nanocatalysts for Enhanced Tumor Ablation. ACS Nano, 2018, 12(11), 11000-11012. （ESI高被引论文）
10. Lili Feng, Dan Yang, Shili Gai, Fei He, Guixin Yang, Piaoping Yang,* and Jun Lin*. Single Bismuth Tungstate Nanosheets for Simultaneous Chemo-, Photothermal, and Photodynamic Therapies Mediated by Near-Infrared Light. Chemical Engineering Journal, 2018, 351, 1147-1158.
9. Lili Feng, Chuanqing Wang, Shili Gai,* Fei He, Rumin Li, Guanghui An, Chongna Zhong, Yunlu Dai, Zailin Yang and Piaoping Yang*. Multifunctional Theranostic Nanoplatform Based on Fe-mTa^₂O^₅@CuS-ZnPc/PCM for Bimodal Imaging and Synergistically Enhanced Phototherapy. Inorganic Chemistry, 2018, 57(9), 4864-4876.
8. Lili Feng, Shili Gai,* Yunlu Dai, Fei He, Chunqiang Sun, Piaoping Yang,* Ruichan Lv, Na Niu, Guanghui An, and Jun Lin*. Controllable Generation of Free Radicals from Multifunctional Heat-Responsive Nanoplatform for Targeted Cancer Therapy. Chemistry of Materials, 2018, 30(2), 526-539.
7. Lili Feng, Shili Gai, Fei He, Yunlu Dai, Chongna Zhong, Piaoping Yang,* and Jun Lin*. Multifunctional Mesoporous ZrO² Encapsulated Upconversion Nanoparticles for Mild NIR Light Activated Synergistic Cancer Therapy. Biomaterials, 2017, 147, 39-52.
6. Lili Feng, Fei He,* Yunlu Dai, Shili Gai,* Chongna Zhong, Chunxia Li, and Piaoping Yang*. Multifunctional UCNPs@MnSiO^₃@g-C^₃N^₄ Nano-platform: Improved ROS Generation and Reduced Glutathione Levels for Highly Efficient Photodynamic Therapy. Biomaterials Science, 2017, 5(12): 2456-2467.
5. Lili Feng, Dan Yang, Fei He,* Shili Gai, Chunxia Li, Yunlu Dai, and Piaoping Yang*. A Core-Shell-Satellite Structured Fe^₃O^₄@g-C^₃N^₄-UCNPs-PEG for T^₁/T^₂ -Weighted Dual-Modal MRI-Guided Photodynamic Therapy. Advanced Healthcare Materials, 2017, 6(18): 1700505.
4. Lili Feng, Fei He,* Yunlu Dai, Bin Liu, Guixin Yang, Shili Gai,* Na Niu, Ruichan Lv, Chunxia Li, and Piaoping Yang*. A Versatile Near Infrared Light Triggered Dual-Photosensitizer for Synchronous Bioimaging and Photodynamic Therapy. ACS Applied Materials & Interfaces, 2017, 9(15): 12993-13008.
3. Lili Feng, Fei He,* Guixin Yang, Shili Gai, Yunlu Dai, Chunxia Li, and Piaoping Yang*. NIR-Driven Graphitic-Phase Carbon Nitride Nanosheets for Efficient Bio-Imaging and Photodynamic Therapy. Journal of Materials Chemistry B, 2016, 4(48): 8000-8008.
2. Lili Feng, Fei He,* Bin Liu, Guixin Yang, Shili Gai, Piaoping Yang,* Chunxia Li, Yunlu Dai, Ruichan Lv, and Jun Lin*. g-C^₃N^₄ Coated Upconversion Nanoparticles for 808 nm Near-Infrared Light Triggered Phototherapy and Multiple Imaging. Chemistry of Materials, 2016, 28(21): 7935-7946.
1. Fei He^#, Lili Feng^#, Piaoping Yang,* Bin Liu, Shili Gai, Guixin Yang, Yunlu Dai, and Jun Lin*. Enhanced Up/Down-Conversion Luminescence and Heat: Simultaneously Achieving in One Single Core-Shell Structure for Multimodal Imaging Guided Therapy. Biomaterials, 2016, 105, 77-88 (Co-first author^#).

荣誉

1. 国家级青年人才
2. 德国“洪堡学者”

奖励

1. 黑龙江黑龙江省高校科学技术特等奖
2. 中国化工学会“化工与京博博士论文奖”提名奖

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冯莉莉